HCID 18003480, compound → HCID 18003524, compound

Participants

Reaction Steps

0.175 g (0.39 mmol) 2Z-Ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-4-yl}-acrylic acid (example 103) were hydrogenated with racemic Ru(OAc)2[3,5-xyl-MeOBIPHEP] catalyst in ethanol at 60° C. and a pressure of 60 bar to give 0.167 g [rac]-2-ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-4-yl}-propionic acid as light grey solid.

Provenance & Evidence