反应详情

A solution of 3-(4-benzyloxy-benzofuran-7-yl)-2Z-ethoxy-acrylic acid ethyl ester (420 mg, 1.15 mmol) (example 120 c]) in methanol (17 ml) was hydrogenated over 10% palladium on charcoal (100 mg) at ambient temperature for 20 h. The catalyst was filtered off, the solvent evaporated under reduced pressure and the residue chromatographed (silica gel, hexane/AcOEt=4/1) to give 240 mg (0.86 mmol, 75%) of the title compound as colorless liquid.

1. filtrationThe catalyst was filtered off
2. customthe solvent evaporated under reduced pressure
3. customthe residue chromatographed (silica gel, hexane/AcOEt=4/1)