HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-Methoxy-2-(4-methoxy-phenylamino)-4-phenylamino-quinazoline dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 2-Chloro-8-methoxy-4-phenylamino-quinazoline | HCID 22639811 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-Methoxy-2-(4-methoxy-phenylamino)-4-phenylamino-quinazoline dihydrochloride | HCID 22639819 | — |
Reaction Steps
A mixture of 2-chloro-8-methoxy-4-phenylamino-quinazoline (1.20 g) and 4-methoxy-aniline (0.66 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (15 ml). 4N HCl in dioxane (0.2 ml) is added. Crystallization from isopropanol and diethylether yields 8-methoxy-2-(4-methoxy-phenylamino)-4-phenylamino-quinazoline dihydrochloride, m.p. 287-289° C., FAB-MS: (M+H)+=373. Analytical data: C22H20N4O2+HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06645774B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-bffd20a83a3040b0a89970994255b2e5 |
| Source note | uspto-grants-2003_11 |