反应详情

温度

110 °C

A mixture of methyl 2-chloro-4-(4-chlorophenyl)-5-oxazolepropionate (805.4 g), 2-methylimidazole (1101.7 g) and dimethyl sulfoxide (2416 mL) was stirred at 110° C. for 8 h and water was added to the obtained mixture. The mixture was extracted with ethyl acetate and the extract was washed with 5% brine. The solvent was evaporated and the residue was dissolved in ethyl acetate (1611 mL) with heating. n-Heptane (4832 mL) was added at 30° C. The precipitated crystals were collected by filtration and washed with ethyl acetate-n-heptane (1:3) to give the title compound (716.6 g, yield: 77.2%).

1. extractionThe mixture was extracted with ethyl acetate
2. washthe extract was washed with 5% brine
3. customThe solvent was evaporated
4. dissolutionthe residue was dissolved in ethyl acetate (1611 mL)
5. temperaturewith heating
6. additionn-Heptane (4832 mL) was added at 30° C
7. filtrationThe precipitated crystals were collected by filtration
8. washwashed with ethyl acetate-n-heptane (1:3)