HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 4,4-Dimethyl-24-dimethylamino-5alpha-chola-8,14-dien-3beta-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 3beta-hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-oic acid-N,N-dimethyl amide | HCID 69873475 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4,4-Dimethyl-24-dimethylamino-5alpha-chola-8,14-dien-3beta-ol | HCID 69873477 | — |
Reaction Steps
The compound is synthesised by lithium aluminium hydride reduction in THF of 3β-hydroxy-4,4-dimethyl-5α-chola-8,14-dien-24-oic acid-N,N-dimethyl amide. 1H-NMR (CDCl3, 400 MHz): δ=5.35 (1H, s); 3.23 (1H, m); 2.85 (2H, m); 2.72 (6H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06645953B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-85d22364071c48a2980ba52db680eeeb |
| Source note | uspto-grants-2003_11 |