Methanol → HCID 54534405, compound

Participants

Reaction Steps

To a solution of cholest-5-ene-3β,16β-diol (700 mg, 1.7 mmol) and sodium acetate (trihydrate) 4.6 g, 34 mmol) in glacial acetic acid (85 mL) was added dropwise, a solution of chromium trioxide in water (1.7 mL) and acetic acid (0.8 mL). After stirring for 16 hours, methanol (5mL) was added and the reaction mixture concentrated at reduced pressure. Water was added and the aqueous phase extracted using dichloromethane. Drying over magnesium sulphate, concentration and purification by flash chromatography gave the title compound (560 mg).

Provenance & Evidence