Methyl iodide → HCID 69873027, compound

Participants

Reaction Steps

To a stirred suspension of KOtBu (900 mg, 8.2 mmol) in tBuOH (25 mL) at 45° C. was added cholesta-4,16-dien-3-one (620 mg, 1.6 mmol) in THF (5 mL) and the whole stirred for 20 minutes. Iodomethane (1 ml) was added and the reaction stirred a further 12 hours., concentrated to one half the original volume and poured into 20 mL ice water. Extraction with ethyl acetate, drying over magnesium sulphate and concentration gave a residue which was purified by flash chromatography to give the title compound (220 mg).

Provenance & Evidence