反应详情

To a suspension of lithium aluminium hydride (80 mg, 2 mmol) in diethyl ether (15 mL) was added 4,4-dimethylcholesta-5,16-dien-3-one (220 mg, 0.5 mmol) in 10 mL ether and the whole was stirred for 1.5 hours. Water was added and the solution filtered through a plug of Celite. The aqueous phase was extracted with ether, washed with 4N HCl, brine, dried over magnesium sulphate and concentrated under reduced pressure to give 3β-hydroxy-4,4-dimethylcholesta-5,16-diene (220 mg).

1. filtrationthe solution filtered through a plug of Celite
2. extractionThe aqueous phase was extracted with ether
3. washwashed with 4N HCl, brine
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated under reduced pressure