HRID479321

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7412

Benzoyl chloride

C7H5ClO

结构：CC(C)CCC[C@@H](C)C1=CC[C@H]2[C@@H]3CC=C4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

HCID20599272

未命名化合物

PRODUCTS

生成物

结构：CC(C)CCC[C@@H](C)C1=CC[C@H]2[C@@H]3CC=C4C(C)(C)[C@@H](OC(=O)c5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C

HCID69873486

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

To a solution of 3βhydroxy-4,4-dimethylcholesta-5,16-diene (220 mg, 0.5 mmol) in pyridine (1.5 mL) at ice bath temperature was added benzoyl chloride (0.1 mL) and the whole stirred for 1.5 hours. Concentration under reduced pressure and purification of the residue by flash chromatography gave 3β-benzoyloxy-4,4-dimethylcholesta-5,16-diene (300 mg).

WORKUP

后处理

concentrationConcentration
customunder reduced pressure and purification of the residue by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a4b1f406ecb94f8385f94440d3590c1e
来源数据集: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06645953B2
来源说明: uspto-grants-2003_11

反应 SMILES

[OH:1][C@H:2]1[CH2:26][CH2:25][C@@:24]2([CH3:27])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:23]2[CH2:22][CH2:21][C@@:20]2([CH3:28])[C@H:8]3[CH2:9][CH:10]=[C:11]2[C@H:12]([CH3:19])[CH2:13][CH2:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1([CH3:30])[CH3:29].[C:31](Cl)(=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>N1C=CC=CC=1>[C:31]([O:1][C@H:2]1[CH2:26][CH2:25][C@@:24]2([CH3:27])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:23]2[CH2:22][CH2:21][C@@:20]2([CH3:28])[C@H:8]3[CH2:9][CH:10]=[C:11]2[C@H:12]([CH3:19])[CH2:13][CH2:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:3]1([CH3:30])[CH3:29])(=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1