HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 4-Dimethylamino-6-aminoquinaldine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-(4-methoxy-2-methylquinolin-6-yl)acetamide | HCID 4785621 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Dimethylamino-6-aminoquinaldine | HCID 17908882 | 77% |
Reaction Steps
The procedure is carried out as in Step A of Example 6, but starting with 57.4 g (0.25 mol) of 6-acetamido-4-methoxyquinaldine, prepared according to J. Amer. Chem. Soc., 1948, 70, 4065, and 100 cm3 of a 40% aqueous dimethylamine solution in 250 cm3 of acetic acid heated at 100° C. for 2 hours in a 1-dm3 autoclave. 38.71 g (77%) of 4-dimethylamino-6-aminoquinaldine are then obtained, after acid-base purification, on carrying out the procedure as in Step A of Example 6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06645964B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-e32621bec5624988a6a429694bb504f9 |
| Source note | uspto-grants-2003_11 |