Sodium Methoxide → HCID 18770850, compound

HRID 479368Notes

Reaction equation

HRID 479368 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([Br:15])[CH:14]=1)[CH2:11][CH2:10][CH2:9][CH2:8]2)(=O)C.C[O-].[Na+]>CO>[Br:15][C:13]1[C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=[C:5]([OH:4])[CH:14]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18770866HCID 18770866, compound

Product 1

HCID 18770850HCID 18770850, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Compound of step b) (6.1 g, 22.66 mmol) is added to MeOH (200 ml) at RT. 1N sodium methoxide in methanol (22.7 ml) is stirred for 15 min. Amberlite IR-120 (H+-form) is added to the mixture until the reaction mixture becomes neutral. The ion exchanger is filtered off, the solvent is evaporated and the crude product is isolated without any further purification as a pale yellow solid.

Workup

  1. addition(H+-form) is added to the mixture until the reaction mixture
  2. filtrationThe ion exchanger is filtered off
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-8f35ce4e04ef4d1fb0dab55058eab68c
Source dataset
uspto-grants-2003_11
Patent number
US06645970B2

Reaction notes

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