Sodium Iodide → HCID 131724208, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl (3,5-difluoro-4-hydroxyphenyl)spiro[2H-1-benzopyran-2,4′-piperidine]-1′-acetate (350 mg), cesium carbonate (412 mg) and sodium iodide (13 mg) was added N,N-dimethylformamide (9 cm3) followed by iodoethane (1.7 mole equiv.). The resulting mixtures were heated to 65° C. with stirring for 3 h. Upon cooling, the reaction was diluted with ethyl acetate (90 cm3) then washed with water (5×35 cm3) and dried (Na2SO4). This solution of crude material was then filtered through a pad of silica before the solvent was removed in vacuo to afford the product in a homogeneous state.

Provenance & Evidence