3-(Methoxymethyl)benzaldehyde → 3-[1-(3-Methoxymethylbenzyl)piperidin-4-yl]-4-(4-chlorophenyl)-3,4-dihydro-2(1H)-quinazolinone

HRID 479467Notes

Reaction equation

HRID 479467 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:24])[CH2:3][CH2:2]1.[CH3:25][O:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[CH:31]=O>>[CH3:25][O:26][CH2:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[CH2:31][N:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH:16]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:24])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 122456233-(Methoxymethyl)benzaldehydeHCID 187708913-(piperidin-4-yl)-4-(4-chlorophenyl)-3,4-dihydro-2(1H)-quinazolinone

Product 1

HCID 99128403-[1-(3-Methoxymethylbenzyl)piperidin-4-yl]-4-(4-chlorophenyl)-3,4-dihydro-2(1H)-quinazolinone

Procedure

In similar way as in Preparation example 11, the title compound was prepared from 3-(piperidin-4-yl)-4-(4-chlorophenyl)-3,4-dihydro-2(1H)-quinazolinone and 3-methoxymethylbenzaldehyde.

Workup

  1. customIn similar way as in Preparation example 11

Sources & evidence

ORD record
ord-7a113e797fac49648e2100c9fdff0c87
Source dataset
uspto-grants-2003_11
Patent number
US06645971B1

Reaction notes

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