Potassium thiocyanate → 4-methyl-N-(2,2,2-trifluoro-1-isothiocyanatoethyl)benzamide

Participants

Reaction Steps

A stirred solution of Example 1B (2.00 g, 8.00 mmol) in acetone (35 mL) at ambient temperature was treated with potassium thiocyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 40% ethyl acetate/hexanes) to provide 1.34 g of the desired product as an off-white solid.

Provenance & Evidence