3-Aminopyridine → 4-Methyl-n-(2,2,2-trifluoro-1-{[(3-pyridinylamino)carbothioyl]amino}ethyl)benzamide

Participants

Reaction Steps

A solution of 3-aminopyridine (145 mg, 1.54 mmol) in benzene (8 mL) at ambient temperature was treated with a solution of Example 1C (500 mg, 1.54 mmol) in benzene (1.5 mL). The reaction mixture was stirred for 1.5 hours, then concentrated to a nominal volume. The white solids which precipitated from solution were collected by filtration and were washed with diethyl ether. Recrystallization from 25% ethyl acetate/hexanes provided the desired product as a white solid.

Provenance & Evidence