4-Methylmorpholine → HCID 18770761, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of Example 26A (458 mg, 1.84 mmol) in THF (10 mL) at −15° C. was treated with isobutyl chloroformate (0.240 mL, 1.84 mmol) followed by N-methylmorpholine (0.200 mL, 1.84 mmol). After 15 minutes, the milky white reaction mixture was treated dropwise with ammonium hydroxide (4.2 mL of 30% reagent, 15.0 mmol). The reaction flask was warmed to −15° C., stirred for 45 minutes, treated with brine (20 mL), and the clear homogeneous mixture was extracted with ethyl acetate (2×40 mL). The organic portions were combined, washed with aqueous KHSO4 solution (15 mL), aqueous NaHCO3 solution (15 mL), and brine (15 mL), and dried (MgSO4). Filtration and removal of solvent provided 232 mg of the desired product a white solid.

Provenance & Evidence