反应详情

温度

165 °C

Equimolar quantities (45.7 mmol) of 2-oxazolidinone and 3-fluoroaniline hydrochloride were combined, heated to 165° C., and stirred for 18 hours. The dark-colored mixture was allowed to cool to ambient temperature and treated with ethanol (125 mL). The suspension was heated to reflux for 1 hour, allowed to cool to ambient temperature, treated with diethyl ether (125 mL), and the suspension was cooled to 0° C. for 2 hours. Filtration provided 5.53 g of the desired product as colorless crystals which were used without further purification.

1. temperatureto cool to ambient temperature
2. temperatureThe suspension was heated
3. temperatureto reflux for 1 hour
4. temperatureto cool to ambient temperature
5. temperaturethe suspension was cooled to 0° C. for 2 hours
6. filtrationFiltration