Chloral Hydrate → 2-methyl-N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

HRID 479492Notes

Reaction equation

[Cl:1][C:2]([Cl:7])([Cl:6])[CH:3](O)[OH:4].[C:8]1([CH3:17])[C:9]([C:14]([NH2:16])=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=1>>[CH3:17][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]([NH:16][CH:3]([OH:4])[C:2]([Cl:7])([Cl:6])[Cl:1])=[O:15]

Participants

Reactant 2

HCID 2707Chloral Hydrate

HCID 107042-Methylbenzamide

Product 1

HCID 33926652-methyl-N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

Procedure

2,2,2-Trichloro-1,1-ethanediol and o-toluamide were processed as described in Example 37C to provide the desired product.

Sources & evidence

ORD record: ord-174e78562ada45149b70cd73eb0030f1
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06645968B2

Reaction notes

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