Benzamide → N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

HRID 479493Notes

Reaction equation

[Cl:1][C:2]([Cl:7])([Cl:6])[CH:3](O)[OH:4].[C:8]([NH2:16])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[Cl:1][C:2]([Cl:7])([Cl:6])[CH:3]([NH:16][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[OH:4]

Participants

Reactant 2

HCID 2331Benzamide

HCID 2707Chloral Hydrate

Product 1

HCID 39323N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

Procedure

2,2,2-Trichloro-1,1-ethanediol and benzamide were processed as described in Example 37C to provide the desired product.

Sources & evidence

ORD record: ord-ac602b82ffc143f8b496715f680d4a7d
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06645968B2

Reaction notes

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