Chloral Hydrate → 4-chloro-N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

HRID 479494Notes

Reaction equation

[Cl:1][C:2]([Cl:7])([Cl:6])[CH:3](O)[OH:4].[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1>>[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH:15][CH:3]([OH:4])[C:2]([Cl:7])([Cl:6])[Cl:1])=[O:14])=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 2707Chloral Hydrate

HCID 120844-Chlorobenzamide

Product 1

HCID 37589644-chloro-N-(2,2,2-trichloro-1-hydroxyethyl)benzamide

Procedure

2,2,2-Trichloro-1,1-ethanediol and 4-chlorobenzamide were processed as described in Example 37C to provide the desired product.

Sources & evidence

ORD record: ord-5a21e0e8561e462394f9aac3edbf7bac
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06645968B2

Reaction notes

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