Potassium cyanate → 4-methyl-N-(2,2,2-trichloro-1-isocyanatoethyl)benzamide

Participants

Reaction Steps

A stirred solution of Example 37D (1.00 g, 3.32.00 mmol) in acetone (20 mL) at ambient temperature was treated with potassium cyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 50% ethyl acetate/hexanes) to provide 620 mg of the desired product as an off-white solid.

Provenance & Evidence