Toluene → HCID 18770593, compound

Participants

Reaction Steps

A suspension of 4-chlorobenzamide (1.32 g, 8.5 mmol), Example 92A (0.96 g, 8.5 mmol), benzotriazole (1.01 g, 8.5 mmol), and MgSO4 (2.00 g, 16.6 mmol) in toluene (50 mL) was treated with p-toluenesulfonic acid (100 mg, 0.53 mmol). The solution was heated at reflux for 48 hours, cooled to ambient temperature, filtered and concentrated to dryness. The crude material was purified by recrystallization from EtOAc/hexanes to provide 1.301 g of the desired product as a white solid.

Provenance & Evidence