5-Amino-2-(trifluoromethyl)pyridine → HCID 178512356, compound

HRID 479545Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=1.[N-:12]([C:15]#[N:16])[C:13]#[N:14].[Na+]>>[C:13]([N:12]=[C:15]([NH2:16])[NH:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([F:11])([F:9])[F:10])=[CH:4][CH:3]=1)#[N:14]

Participants

Reactant 2

HCID 27377445-Amino-2-(trifluoromethyl)pyridine

HCID 4350929Sodium dicyanamide

Product 1

HCID 178512356HCID 178512356, compound

Procedure

A solution of 5-amino-2-(trifluoromethyl)pyridine and sodium dicyanamide was processed as described in Example 71A to provide the desired product.

Sources & evidence

ORD record: ord-67b6d10271b741df9980250b152fbebe
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06645968B2

Reaction notes

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