Sodium borohydride → [5-(Benzyloxy)quinolin-6-yl]methanol

HRID 47956Notes

Reaction equation

HRID 47956 reaction equation
[CH2:1]([O:8][C:9]1[C:18]([CH:19]=[O:20])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][CH:13]=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([O:8][C:9]1[C:18]([CH2:19][OH:20])=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][CH:13]=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 234318215-(Benzyloxy)quinoline-6-carbaldehyde

Product 1

HCID 23431816[5-(Benzyloxy)quinolin-6-yl]methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Treatment of 5-(benzyloxy)quinoline-6-carbaldehyde with sodium borohydride in methanol following the procedure described for Example 4, step 1 provides [5-(benzyloxy)quinolin-6-yl]methanol.

Sources & evidence

ORD record
ord-e987ef9495094d7d96ca7241fca837ce
Source dataset
uspto-grants-2004_03
Patent number
US06700001B2

Reaction notes

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