HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 2-(2,6-Difluorophenyl)-4-(4-formylphenyl)oxazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Reactant | 2-(2,6-Difluorophenyl-)4-(4-(2-phenylethenyl)phenyl)oxazoline | HCID 69548898 | — |
| Catalyst | Ruthenium trichloride hydrate | HCID 6093376 | — |
| Solvent | Acetonitrile acetone water | HCID 18799168 | — |
| Product | 2-(2,6-Difluorophenyl)-4-(4-formylphenyl)oxazoline | HCID 12056636 | 97.5% |
Reaction Steps
At 0° C., 2-(2,6-difluorophenyl-)4-(4-(2-phenylethenyl)phenyl)oxazoline (7.22 g, 20 mmol) and sodium metaperiodate (8.55 g, 20 mmol) were suspended in acetonitrile/acetone/water (1:1:1, 180 ml), and a catalytic amount of ruthenium trichloride hydrate was added. Following extractive work-up with ethyl acetate and column chromatography, 5.6 g of the aldehyde were obtained as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06645984B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-b438d3c89a524794985ad3aecba2fad6 |
| Source note | uspto-grants-2003_11 |