(2S)-4-[5-(benzyloxy)quinolin-6-yl]-2-hydroxybutyl 4-methylbenzene sulfonate → HCID 136330645, compound

HRID 47959Notes

Reaction equation

HRID 47959 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH2:12][C@@H:13]([OH:34])[CH2:14][CH2:15][C:16]2[C:17]([O:26]CC3C=CC=CC=3)=[C:18]3[C:23](=[CH:24][CH:25]=2)[N:22]=[CH:21][CH:20]=[CH:19]3)(=[O:10])=[O:9])=[CH:4][CH:3]=1>[Pd].C(O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH2:12][C@@H:13]([OH:34])[CH2:14][CH2:15][C:16]2[C:17]([OH:26])=[C:18]3[C:23](=[CH:24][CH:25]=2)[N:22]=[CH:21][CH:20]=[CH:19]3)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 20631714(2S)-4-[5-(benzyloxy)quinolin-6-yl]-2-hydroxybutyl 4-methylbenzene sulfonate

Product 1

HCID 136330645HCID 136330645, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Treatment of (2S)-4-[5-(benzyloxy)quinolin-6-yl]-2-hydroxybutyl 4-methylbenzene sulfonate with palladium on carbon (10 wt. %) in ethanol following the procedure described in Example 9 provides (2S)-2-hydroxy-4-(5-hydroxy-quinolin-6-yl)butyl 4-methylbenzenesulfonate.

Sources & evidence

ORD record
ord-80bfa738a6324dccbb5d740c88142583
Source dataset
uspto-grants-2004_03
Patent number
US06700001B2

Reaction notes

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