Hydrochloric Acid → HCID 86759249, compound

Participants

Reaction Steps

A solution of 3,4-dimethoxyaniline (1.76 g, 11.49 mmol) and ethyl ∀-formyl-4-methoxyphenylacetate (2.81 g, 1.1 eq) in toluene (20 ml) is refluxed for 18 hours. After cooling, the reaction mixture is diluted with toluene (10 ml) and then acidified with 10% HCl. After extraction, the organic phase obtained is dried over MgSO4 and then evaporated under reduced pressure. The residue is purified by chromatography on silica gel (eluent: 7/3 PE/EtOAc) to give 2.67 g (65%) of compound 30 in the form of a pale yellow solid.

Provenance & Evidence