Reaction Steps
Mp, 221-224° C. 62.1% Yield. IR νmax (nujol) 3448, 3344, 1735, 1635 (sh), 1615 cm−1. 1H NMR (CDCl3) δ 2.40 (3H, s), 4.14 (2H, s), 4.74 (2H, s), 6.38 (1H, d, J=8.1 Hz), 6.54 (1H, t, J=6.9 Hz), 6.81 (1H, d, J=7.5 Hz), 7.05-7.53 (8H, m). Analyses: Calc'd for C26H22N2O5.0.5H2O: C, 69.17; H, 5.13; N, 6.20. Found: C, 69.07; H, 5.06; N, 6.17. 2-(3-(Biphenyl-2-ylmethyl)-8-carbomethoxymethyloxy-2-isopropylindolizin-1-yl)glyoxylamide 58c. Mp, 139-141° C. 59% Yield. IR νmax (CHCl3) 3462, 3382, 3292, 1737, 1686, 1639 cm−1. 1H NMR (CDCl3) δ 1.32 (6H, d, J=7.0 Hz), 3.42 (1H, sept, J=7.0 Hz), 4.19 (2H, s), 4.59 (2H, s), 6.23 (1H, d, J=7.4 Hz), 6.45 (1H, t, J=7.0 Hz), 6.69 (1H, d, J=7.8 Hz), 6.91 (1H, br.s), 7.03-7.58 (l1H, m). Analyses: Calc'd for C28H26N2O5.1.3H2O: C, 68.09; H, 5.84; N, 5.67. Found: C, 68.02; H, 5.74; N, 5.65.
