Methyl iodide → HCID 10205828, compound

HRID 479640Notes

Reaction equation

[CH2:1]([C:4]1[CH:29]=[C:28]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:27]=[CH:26][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[O:17][CH:16]([C:21]([O:23]CC)=[O:22])[CH2:15][CH2:14]2)[CH2:2][CH3:3].I[CH3:38]>>[CH2:1]([C:4]1[CH:29]=[C:28]([O:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:27]=[CH:26][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[O:17][C:16]([CH3:38])([C:21]([OH:23])=[O:22])[CH2:15][CH2:14]2)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18772274HCID 18772274, compound

Product 1

HCID 10205828HCID 10205828, compound

Procedure

The title compound was prepared from ethyl 6-(3-(2-propyl-4-phenoxyphenoxy)propoxy)-chromane-2-carboxylate (Example 13) following the procedures described in Example 2, Step A, employing iodomethane instead of iodopropane, and subsequently hydrolyzed following the procedure in Example 1, Step C.

Sources & evidence

ORD record: ord-6c3d99a99d0f46258df905d795bd9b92
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06645997B2

Reaction notes

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