HCID 11210586, compound → HCID 10207241, compound

HRID 479650Notes

Reaction equation

HRID 479650 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:16][CH2:17][CH2:18][CH2:19]Br.[CH2:21]([C@:23]1([C:34]([O:36]C)=[O:35])[CH2:32][CH2:31][C:30]2[C:25](=[CH:26][C:27]([OH:33])=[CH:28][CH:29]=2)[O:24]1)[CH3:22]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:16][CH2:17][CH2:18][CH2:19][O:33][C:27]1[CH:26]=[C:25]2[C:30]([CH2:31][CH2:32][C@:23]([CH2:21][CH3:22])([C:34]([OH:36])=[O:35])[O:24]2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 11210586HCID 11210586, compoundHCID 11345381(2R)-methyl 2-ethyl-7-hydroxychromane-2-carboxylate

Product 1

HCID 10207241HCID 10207241, compound

Procedure

The title compound was prepared following the procedures described in Example 1, Steps B-C employing 3-bromopropyl 2-chloro-4-(4-fluorophenoxy)phenyl ether (Example 20, Step A) instead of 4-(3-bromopropoxy)-3-propylphenyl phenyl ether, and (2R)-methyl 2-ethyl-7-hydroxychromane-2-carboxylate (Example 25, Step E) instead of ethyl 7-hydroxychromane-2-carboxylate.

Sources & evidence

ORD record
ord-28ebabe189064415ac2d99d5c105a90a
Source dataset
uspto-grants-2003_11
Patent number
US06645997B2

Reaction notes

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