2-chloro-4-phenoxyPhenol → (2r)-7-(3-(2-Propyl-4-(4-isobutylphenoxy)phenoxy)propoxy)-2-propylchromane-2-carboxylic acid

HRID 479651Notes

Reaction equation

HRID 479651 reaction equation
[CH2:1]([C@:4]1([C:15]([O:17]C)=[O:16])[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([OH:14])=[CH:9][CH:10]=2)[O:5]1)[CH2:2][CH3:3].[CH2:19]([C:22]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][C:32]([CH2:35][CH:36]([CH3:38])[CH3:37])=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:23]=1[OH:39])[CH2:20][CH3:21].Cl[C:41]1[CH:46]=C(OC2C=CC=CC=2)C=C[C:42]=1O>>[CH2:19]([C:22]1[CH:27]=[C:26]([O:28][C:29]2[CH:30]=[CH:31][C:32]([CH2:35][CH:36]([CH3:38])[CH3:37])=[CH:33][CH:34]=2)[CH:25]=[CH:24][C:23]=1[O:39][CH2:42][CH2:41][CH2:46][O:14][C:8]1[CH:7]=[C:6]2[C:11]([CH2:12][CH2:13][C@:4]([CH2:1][CH2:2][CH3:3])([C:15]([OH:17])=[O:16])[O:5]2)=[CH:10][CH:9]=1)[CH2:20][CH3:21]

Participants

4

Reactant 3

HCID 107276802-chloro-4-phenoxyPhenolHCID 18772259HCID 18772259, compoundHCID 59110703(2r)-Methyl 2-propyl-7-hydroxychromane-2-carboxylate

Product 1

HCID 10166486(2r)-7-(3-(2-Propyl-4-(4-isobutylphenoxy)phenoxy)propoxy)-2-propylchromane-2-carboxylic acid

Procedure

The title compound was prepared following the procedures described in Example 17, Step B-C employing (2R)-methyl 2-propyl-7-hydroxychromane-2-carboxylate instead of ethyl 7-hydroxychromane-2-carboxylate, and 2-propyl-4-(4-isobutylphenoxy)phenol (U.S. Pat. No. 6,008,237) instead of 2-chloro-4-phenoxyphenol.

Sources & evidence

ORD record
ord-44f1c4665bc144a29b272fa34a1973a8
Source dataset
uspto-grants-2003_11
Patent number
US06645997B2

Reaction notes

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