HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sodium Azide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(Pyridin-2-yl)-1,3-thiazole-4-carboxylic acid | HCID 15623090 | — |
| Reactant | 2-(4-Pyridinyl)-4-thiazolylcarbonylazide | HCID 18771740 | — |
| Solvent | Water | HCID 962 | — |
| Product | Sodium Azide | HCID 33557 | — |
| Product | 2-Azidopyridine | HCID 10964472 | — |
Reaction Steps
In a manner similar to that described for the preparation of 2-(4-pyridinyl)-4-thiazolyl-carbonylazide, 2-(2-pyridinyl)-4-thiazolylcarboxylic acid (1.0 g)was treated successively with NaOH, oxalyl chloride and a solution of NaN3 in water to give the 2-pyridinyl azide as a pale brown solid: m.p. 112-114° C. MS m/z: 232 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06645990B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-3062b60c2c5248b7b53dff396956d995 |
| Source note | uspto-grants-2003_11 |