4-(1-Pyrrolidinyl)piperidine → HCID 18771768, compound

HRID 479659Notes

Reaction equation

HRID 479659 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[N:10]1([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13][CH2:12][CH2:11]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:7]=1

Participants

4

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 18771768HCID 18771768, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7] To 6-bromo-2-pyridinecarboxaldehyde (400 mg, 2.15 mmol) was added 4-(1-pyrrolidinyl)-piperidine (500 mg, 3.22 mmol) in dry CH2Cl2 (15 mL) to give 2-bromo-6-[4-(1-pyrrolidinyl)-piperidinylmethyl]pyridine as a pale yellow solid. MS m/z: 326.1(M+2H). Calc'd for C15H22BrN3: 324.26.

Sources & evidence

ORD record
ord-9a2dfa9e0636494a9320b9cf48f37dc5
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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