6-Bromopyridine-2-carbaldehyde → HCID 18771960, compound

HRID 479663Notes

Reaction equation

HRID 479663 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([C:12](=O)N)[CH2:7]1)=[O:5])[CH3:2].[Br:17][C:18]1[N:23]=[C:22](C=O)[CH:21]=[CH:20][CH:19]=1>>[CH2:1]([N:3]([CH2:15][CH3:16])[C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][C:22]2[CH:21]=[CH:20][CH:19]=[C:18]([Br:17])[N:23]=2)[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27570096-Bromopyridine-2-carbaldehydeHCID 60675000HCID 60675000, compound

Product 1

HCID 18771960HCID 18771960, compound

Procedure

14] N,N-Diethylcarbamoyl-piperidine-3-carboxamide (0.92 mL, 5.92 mmol) was added to a solution of 6-bromo-2-pyridinecarboxaldehyde (1.0 g, 5.38 mmol) to give N,N-diethyl 1-(6-bromopyridin-2-ylmethyl)piperidine-3-carboxamide as a colorless oil. MS m/z: 354.1 (M+H). Calc'd for C16H24BrN3O—354.29.

Sources & evidence

ORD record
ord-ace77e78bc054be38f3307aa7db5e827
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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