Trifluoroacetic acid → HCID 18772069, compound

Participants

Reaction Steps

In an oven-dried, 25-mL, round-bottomed flask were placed N-[6-propylpyridine]-N′-[4-[N-Bocamino]pheny]-4-thiazolyl]urea (55 mg, 0.12 mmol, Example 187), thioanisole (0.35 mL) in CH2Cl2 (10 mL). TFA (0.35 mL) was added, the mixture was stirred at RT for 6 h then concentrated in vacuo. Purification by flash chromatography on silica gel [EtOAc/hexane (extracted with aq. NH4OH), 40:60] afforded the title compound. MS m/z: 354.0 (M+H). Calc'd for C18H19N50S: 353.13.

Provenance & Evidence