Trifluoroacetic acid → HCID 18771646, compound

Participants

Reaction Conditions

Reaction Steps

2-({6-[3-(2-Pyridin-4-yl-thiazol-4-yl)-ureido]-pyridin-2-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (52 mg, 0.102 mmol) in MeOH (10 mL) was treated with TFA (0.1 mL, 1.3 mmol). The resulting mixture was heated at 50° C. for 24 h. The reaction mixture was cooled to RT and neutralized to pH between 8-9. Solvent was removed. The residue was partitioned between H2O and CHCl3. The organic layer was washed with H2O, brine, dried over MgSO4, and concentrated to give a yellow solid. MS m/z: 410.2 (M+H). Calc'd. for C20H23N7OS-409.17.

Provenance & Evidence