HCID 18771577, compound → HCID 24886508, compound

HRID 479710Notes

Reaction equation

HRID 479710 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:3]1>CCCCCC.CCO>[CH3:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]3[N:20]=[C:21]([C:24]4[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=4)[S:22][CH:23]=3)=[O:17])[CH:12]=[CH:11][CH:10]=2)[CH2:3]1

Participants

3

Reactant 1

HCID 18771577HCID 18771577, compound

Product 1

HCID 24886508HCID 24886508, compound

Reagents, catalysts & solvents 1

HCID 21879635Ethanol hexaneSolvent

Procedure

1-[6-(3-Methyl-piperidin-1-ylmethyl)-pyridin-2-yl]-3-(2-pyridin-4-yl-thiazol-4-yl)-urea (50 mg, 0.12 mmol, Example 78) was separated by chiral HPLC (Chiraltech Chiralcel OJ 50×4.6 mm i.d.) using hexane/EtOH/DEA (90:10:0.2) to give a white solid. MS m/z: 409.3 (M+H). Calc'd for C21H24N6OS-408.52.

Workup

  1. customto give a white solid

Sources & evidence

ORD record
ord-f8ae7133541d45f7b655d04fb6db56c4
Source dataset
uspto-grants-2003_11
Patent number
US06645990B2

Reaction notes

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