Trifluoroacetic acid → HCID 18771578, compound

Participants

Reaction Steps

To a stirred solution of 4-(2-{6-[3-(2-bromo-thiazol-4-yl)-ureido]-pyridin-2-yloxy}-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (285 mg, 0.54 mmol) in anhydrous CH2Cl2 (6 mL) at RT, under N2, TFA (1.5 mL) was added. After 1.5 h the solvent was evaporated in vacuo. The residue was carefully treated with a saturated solution of NaHCO3 (aq) (10 mL), the precipitate was filtered off, washed with Et2O (3×5 mL) and dried in a vacuum oven at 60° C. for 5 h to yield the title compound as a white amorphous solid. MS m/z: 426.2, 428.2 (M+H). Calc'd. for C16H20BrN5O2S-426.33.

Provenance & Evidence