4-Fluoroaniline → (E)-N-(4-Fluorophenyl)-2-Phenylethenesulfonamide

HRID 479719Notes

Reaction equation

[CH:1](/[S:9](Cl)(=[O:11])=[O:10])=[CH:2]\[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[CH:1](/[S:9]([NH:18][C:17]1[CH:19]=[CH:20][C:14]([F:13])=[CH:15][CH:16]=1)(=[O:11])=[O:10])=[CH:2]\[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 5369377(E)-2-phenylethene-1-sulfonyl chloride

Product 1

HCID 730266(E)-N-(4-Fluorophenyl)-2-PhenylethenesulfonamideYield 58.7%

Procedure

A solution of (E)-styrylsulfonyl chloride (10 mmol) and 4-fluoroaniline (10 mmol) was subjected to General Procedure 1, part B. The title compound, melting point 83-85° C., was obtained 58.7% yield.

Sources & evidence

ORD record: ord-959422556871477aa48394975e923e5c
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06646009B2

Reaction notes

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