反应详情

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

1. customwas bubbled in dry hydrochloric acid at 0° C.
2. temperaturethe solution was refluxed until all the solids
3. dissolutiondissolved
4. customThe solvents were removed under reduced pressure
5. dissolutionthe residue dissolved in ethyl acetate
6. washwashed with saturated sodium bicarbonate, brine
7. concentrationconcentrated