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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 479754Generated: October 29, 2026

Oxalyl chloride → 1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedione

https://huagongshe.com/reaction/479754

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxalyl chlorideHCID 65578—
Reactant1-(4-Fluorophenyl)-2-(4-pyridyl)ethanediolHCID 18771502—
Product1-(4-Fluorophenyl)-2-(4-pyridinyl)-1,2-ethanedioneHCID 11790992—

Reaction Steps

Oxidation of 1-(4-fluorophenyl)-2-(4-pyridyl)ethanediol according to the oxalyl chloride method of Swern [J. Org. Chem., 44, p 4148, 1979)] gave the titled dione following extractive workup and recyrstallization from hexanes m.p. 85-86.5° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06645989B2
Source datasetuspto-grants-2003_11
ORD IDord-0a06086c93b74e6b9cae7f786da1012d
Source noteuspto-grants-2003_11