Cyclobutanecarbonyl chloride → HCID 20598112, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 203 (0.276 mmol, 102 mg) in CH2Cl2 (2 mL) at 0° C. was treated with cyclobutanecarbonyl chloride (1.5 equiv, 0.414 mmol, 50 μL) and diisopropylethylamine (1.5 equiv, 0.414 mmol, 72 μL) under Ar. After warming to 25° C and stirring for 12 h, the reaction mixture was purified directly by chromatography (PTLC, SiO2, 20 cm×20 cm, 1 mm, 8:1 hexane-acetone) which provided 204 (100 mg, 124 mg theoretical, 81%) as a yellow oil: Rf 0.27 (SiO2, 8:1 hexane-acetone); LRMS m/z 451 (M+, C28H35ClN2O, requires 451).

Provenance & Evidence