反应详情

Diethyl(2-ethoxy-5-pyridylaminomethylene)malonate (6.04 g) was added to diphenyl ether (20 mL) preheated to 230° C. Heating was continued for 0.5 h, the reaction flask removed from the oil bath, and the mixture allowed to cool to ambient temperature. The product was triturated with 1:1 ether:hexanes, collected, rinsed with ether, and dried to gave 2.98 g of ethyl 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate as a tan solid.

1. custompreheated to 230° C
2. temperatureHeating
3. customthe reaction flask removed from the oil bath
4. customThe product was triturated with 1:1 ether
5. customhexanes, collected
6. washrinsed with ether
7. customdried