反应详情

A mixture of ethyl 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (2.98 g), 1N NaOH (50 mL) and ethanol (10 mL) was heated at reflux for 2 h. The reaction mixture was cooled in an ice bath, acidified, and the resulting precipitate collected, rinsed with water and dried to give 2.42 g of 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid as a beige solid.

1. temperaturewas heated
2. temperatureat reflux for 2 h
3. temperatureThe reaction mixture was cooled in an ice bath
4. customthe resulting precipitate collected
5. washrinsed with water
6. customdried