Formaldehyde → HCID 11807514, compound

Participants

Reaction Steps

To a solution of N-benzyloxycarbonyl-L-valine (25.1 g, 0.1 mol) in toluene (500 ml) was added paraformaldehyde (4.0 g) and p-toluenesulfonic acid monohydrate (1.0 g), and the mixture was refluxed for 30 minutes, during which the generated water was removed by a Dean-stalk apparatus. The reaction solution was washed successively with 5% aqueous sodium hydrogen carbonate solution and saturate brine, dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from toluene to give the desired compound (25.0 g, yield: 95%).

Provenance & Evidence