HCID 9857659, compound → (2S,3S)-3-Amino-1,1,1-trifluoro-4-methylpentan-2-ol(WXFC0747)

Participants

Reaction Steps

N-[(1S,2S)-3,3,3,-trifluoro-2-hydroxy-1-(isopropyl)propyl]-carbamic acid benzyl ester (740 g, 2.42 mol) obtained in Example 5 was dissolved in ethyl acetate (1500 ml), and thereto was added 20% palladium hydroxide (30 g), and the mixture was stirred at room temperature for 7 hours under hydrogen atmosphere. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give the desired compound (420 g, yield:quantitative) as an oil.

Provenance & Evidence