HCID 69537576, compound → HCID 69537586, compound

Participants

Reaction Steps

N-[(1S,2S)-1-(4-Benzyloxyphenyl)methyl-3,3,3-trifluoro-2-hydroxypropyl]carbamic acid benzyl ester (2.19 g, 4.8 mmol) was dissolved in ethyl acetate (30 ml), and thereto was added 20% palladium hydroxide (1 g). The mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give the desired compound (1.11 g, yield: quantitatively) as an oil.

Provenance & Evidence