Triethyl phosphite → Phosphonic acid, [(4-fluoro-3-phenoxyphenyl)methyl]-, diethyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluoro-3-phenoxybenzyl bromide (28.1 g, 100 mmol) and triethyl phosphite (18.27 g, 110 mmol) is heated at 90° C. for 30 minutes while allowing some low boiling materials to distill off. The resultant mixture is heated at 140° C. for 3.5 hours and distilled at 120° C./2 mmHg to give the title product as a syrup (32.1 g, 95% yield) which is identified by 1H and 19F NMR spectral analyses.

Provenance & Evidence