Sodium Hydroxide → 4,4'-Dihydroxybenzophenone

HRID 479910Notes

Reaction equation

HRID 479910 reaction equation
O[C:2]1[C:3]([OH:18])=[C:4](O)[C:5](O)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[OH-].[Na+].C1([O-:27])C=CC=CC=1.[Na+].[Na+].C1([O-])C=CC=CC=1.ClC([SiH2]OC)Cl>>[OH:18][C:3]1[CH:4]=[CH:5][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([OH:27])=[CH:11][CH:10]=2)=[O:8])=[CH:15][CH:2]=1

Participants

5

Reactant 4

HCID 14798Sodium HydroxideHCID 15819849DinatriumphenolatHCID 18916270TetrahydroxybenzophenoneHCID 131724212Dichloromethylmethoxysilane

Product 1

HCID 691504,4'-Dihydroxybenzophenone

Procedure

Synthesis I: A solution of tetrahydroxybenzophenone (Aldrich Chemical) is treated with sufficient caustic, i.e. sodium hydroxide, to prepare a disodium phenolate salt. This salt solution is mixed at a two to one molar ratio with dichloromethylmethoxysilane (Aldrich, United Chemicals) to yield 2,2′ di-(dimethoxymethylsilyoxy), 4,4′dihydroxy-benzophenone having the structure shown in FIG. 8(a).

Workup

  1. customSynthesis I

Sources & evidence

ORD record
ord-20b67363510049ddaef047e91e69fc16
Source dataset
uspto-grants-2003_11
Patent number
US06649212B2

Reaction notes

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