Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Fluoro-3-nitrobenzene | HCID 9823 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 178418785 | HCID 178418785 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 16128758 | HCID 16128758 | 58% |
Reaction Steps
A mixture of 3-fluoronitrobenzene (1.78 ml; 16.7 mmol), methyl imidazole-4-carboxylate and potassium carbonate (2.3 g; 16.7 mmol) in 10 ml NMP was heated to 120° C. in a nitrogen atmosphere overnight. The cooled mixture was poured into water (100 ml), the precipitate was filtered off, washed with water and dried to yield 6c (2.38 g; 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06649609B2 |
|---|
| Source dataset | uspto-grants-2003_11 |
|---|
| ORD ID | ord-a756f9cffba9475ab56ecee20fbd0657 |
|---|
| Source note | uspto-grants-2003_11 |
|---|
